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ea0099p71 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Causal associations between adiposity markers and nuclear magnetic resonance spectroscopy-measured lipids in plasma: a mendelian randomisation study in 110,000 mexican adults

Lin Beryl , Aguilar Ramirez Diego , Alegre-Diaz Jesus , Staplin Natalie , G Herrington William , Baca Paulina , Gonzalez Carballo Carlos , Ramirez-Reyes Raul , Rivas Fernando , Gnatiuc-Friedrichs Louisa , Hill Michael , Romer Fredrik , Torres Jason , Trichia Eirini , Wade Rachel , Genetics Center Regeneron , Collins Rory , Emberson Jonathan , Berumen Jaime , Kuri-Morales Pablo , Tapia-Conyer Roberto

Background: The genotyped Mexico City Prospective Study (MCPS) cohort enables the causal effects of adiposity on lipids to be explored in an overweight Hispanic population with scarce statin use.Methods: MCPS participants aged 35-84 years, with baseline nuclear magnetic resonance measurements of blood lipids, and not using lipid-lowering therapy at recruitment were included. Using the Mendelian randomisation one-sample ratio method, univariable and multi...

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Causal associations between adiposity markers and nuclear magnetic resonance spectroscopy-measured lipids in plasma: a mendelian randomisation study in 110,000 mexican adults

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